What is the nStride autologous protein injection, and how does it work?


So, the n-STRIDE autologous blood protein
injection is a good option for treatment of osteoarthritis in the knee, and now in other
joints as well. It is a simple procedure, involves taking blood from the patient, purifying
proteins from that blood and injecting a small amount of protein rich fluid back into the
knee in a minimally invasive manner. There is no anaesthetic involved and it is essentially
what we call a walk-in walk-out procedure. When comparing this type of injection to other
injections such as steroids or lubricants, the injection involves use of the patient’s
own blood proteins and therefore no drugs are injected. Secondly, it is a natural biological
treatment and thirdly, the mechanism in which it acts is such that it is aimed at trying
to reduce or slow the progress of osteoarthritis, whereas the other injections just try to improve
the symptoms. So, the treatment is a treatment for osteoarthritis.
Initially, the treatment has been brought to the UK for treatment of osteoarthritis
of the knee, but through the company that promotes this product, I have permission to
treat patients with osteoarthritis in other joints. So therefore, I have treated patients
with osteoarthritis in the hip and in the ankle as well, but predominantly the treatment
has been available for osteoarthritis in the knee. It is indicated for patients with moderate
arthritis, not severe arthritis. It is not a substitute for total knee replacement. It’s
ideal in patients who we call the gap generation where keyhole surgery is not going to really
give them a great deal of benefit. We know that keyhole surgery for osteoarthritis doesn’t
yield very good results and in patients with moderate arthritis their arthritic changes
are not severe enough to need a total knee replacement, but they still remain quite symptomatic
and it is in those patients where we aim to get the most benefit. So, the treatment protocols for the n-STRIDE
autologous blood protein injection involves a single injection of the n-STRIDE blood protein
into the knee. So therefore, only one injection is required. We then reassess the patient
at regular intervals to see how they’re getting on. In my data collection study which is part
of a larger data collection study with a number of centres across Europe, we are assessing
the patients over a two-year period. We’re defining success as symptomatic improvement
for greater than 12 months, because we know that some patients do get benefit from steroid
injections or lubricant injections for four to six months. So therefore, we want to define
our patients with positive results as better than those compared to steroids or lubricants. So, the n-STRIDE autologous blood protein
injection is a very simple minimally invasive procedure that involves taking the patient’s
own blood from the patient’s arm, purifying proteins from that blood through two simple
centrifuge processes which take a total of approximately 20 minutes. This leaves approximately
three mils of protein rich fluid which is injected through a very small needle into
the patient’s knee. The procedure is carried out under aseptic conditions and we have seen
no major side effects. I’ve carried out a data collection study and in that data collection
study we look for adverse reactions and the only reactions that have been reported have
been temporary transient pain, swelling and stiffness for no more than 24 to 48 hours.
We have seen no other adverse reactions. Of course, in some patients it may not work but
we see greater than 75 percent success rates so far. Again, it’s a natural biological treatment
there are no other drugs injected into the knee and therefore there are no foreign body
reactions that we have seen either.

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