Type 1 Diabetes: from Cubism to a cure | Robin Goland | TEDxMet

Type 1 Diabetes: from Cubism to a cure | Robin Goland | TEDxMet

Translator: Jim Taylor
Reviewer: Denise RQ Amelia was diagnosed
with type 1 diabetes at the age of ten. She looked pretty good despite a difficult
– some may say devastating – diagnosis. Her parents, who were with her,
looked a lot worse. Type 1 diabetes occurs
because the immune system attacks the insulin producing cells
of the pancreas. People with diabetes struggle
each day to take care of it. It’s really hard,
especially for the children. High blood sugars can lead
to devastating complications, like blindness and amputation. I make it a point to meet all the newly diagnosed patients
and their families when they come to
the Naomi Berrie Diabetes Center that I co-direct. When I met Amelia and her family,
her mother told me an astonishing thing. She said that her grandfather,
Amelia’s great-grandfather, was the first person
to receive insulin at my hospital. I was stunned. I have in my office the multi-volume chart of the first person
to get insulin for diabetes at New York Presbyterian Hospital. I use his pictures to teach
the Columbian medical students about diabetes. “Are you related to Edwin Manheimer?” “My name is Karen Manheimer”, she said. Edwin Manheimer
was admitted to the hospital for a recent diagnosis
of type 1 diabetes in 1922. Back then, type 1 diabetes
was a fatal disease. He was 11 years old.
He weighed 30 pounds. He couldn’t lift his head up
from the pillow. It became too sad for his family
to take care of him at home. They brought him to the hospital. It’s really sad for me
to show these pictures, because we take care of a lot of patients,
a lot of children, with type 1 diabetes and before 1922 they all would have died. The situation for type 1 diabetes
was unchanged before 1922 for thousands of years. The first description of diabetes
is shown on the Ebers Papyrus from thousands of years ago. Diabetes has been described in antiquity as the melting of the flesh
on the limbs into urine. Life was said to be short and unpleasant.
It could have been a description of Edwin. All of that changed in 1922, when an orthopedic surgeon
and a medical student made a revolutionary discovery. They extracted the hormone insulin
from beagle dogs and found that it lowered sugar
in the blood and apparently cured diabetes. Edwin’s doctors in New York City
wrote to the scientists in Toronto after hearing of this startling research and asked if they would consider
sending this newly discovered hormone to try in their dying little patient
at the New York Presbyterian Hospital. The insulin came in the mail, as it was described,
covered in roots and twigs. The chart goes on to say the doctors
injected it into the little boy and he walked. Edwin, weighing 30 pounds at admission,
weighed 60 pounds at discharge. The nurses notes
are the most extraordinary part of this amazing chart. The nurses, a few weeks after
the treatment with insulin was started, began describing Edwin as poorly behaved. He ran in the halls.
He stole food from the nurses station He was generally annoying! In short, he was a normal 11 year old boy. He was discharged from the hospital
taking insulin among the first people in the world. He grew up. He started a family. He worked in a family chemical company
that his family still runs today. By all accounts he was a lovely man,
a volunteer for the boy scouts. He developed devastating complications
of diabetes. His two sons do not remember him
when he wasn’t blind. He died of these complications
at the age of 50. Insulin treatment back then was barbaric. The outlook for people diagnosed today
is much brighter for a healthy, normal life expectancy
free of terrible complications. Thanks to scientists
collaborating together on a study called the NIH Trial Net Study
we have found ways to identify type 1 diabetes
in relatives of our patients even before it occurs. We’re working for the future
to prevent diabetes so that no additional family members
will develop it. Amelia, five years after her diagnosis
of diabetes, is doing great. Even her parents are doing great! Jay Kee developed type 1 diabetes
at 11 months old. Among his first words
were momma, dadda and pump. That’s his insulin pump.
Really shouldn’t happen. He takes his blood sugar by finger stick
8-15 times a day. He inserts his pump. Patients use a glucose censor that they have to insert
every week or so under their skin. It’s hard. The strides in the clinical care
have been spectacular. It is not enough. Jay Kee and his family,
and all of my patients, worry a little bit about their diabetes
every day, sometimes more. Too low a blood sugar can cause coma. Too high blood sugars,
over a long period of time, can lead to complications. We need more. The advances have been great,
but they’re arguably incremental steps over the discovery of insulin
made in 1922. We perhaps need a revolution, a new way of looking
at a world without diabetes. I recently went to see
the cubist exhibit at the MET. I discovered it was about science. A patient observed to me that Picasso and Braque
are the scientists of the art world. They worked together
to discover new ways to look at the world. The results were unimaginable
before they came along. You can’t see it until you see it. Their work led to a revolution
that changed the world forever much the ways the discoveries
of Banting and Best changed the world forever for my patients. I believe we are poised on the brink
of a revolution in the science of diabetes and it was with this thought in mind that we started
the Naomi Berrie Diabetes Center. We want to be ready. We put the research labs
right next to the doctors offices where the patients are cared for. It seemed to us the
fasted way to the cure is to have everybody
talking to each other the doctors taking care of the patients,
the scientists trying to cure it, and to allow the patients
access to the scientists as the best way to provide
hope and optimism for the future. What I didn’t imagine,
and what turned out to be more powerful, were the insights
the patients would provide to the scientists. We give lab tours
to our patients and families, including this one,
our diabetes camp for children. Our little campers go on outings
to New York City landmarks and museums, like the MET. These under-served kids, often it’s the only time
they leave their neighbourhood, except to go to the doctor. This year, 29 of 30 kids said the lab tour was the best part
of diabetes camp. One kid said bowling was better! Doctor Rudy Leibel,
my co-director and basic scientist, showed the children
laboratory mice with diabetes. The child in the red hat was concerned
that their blood sugar was very high. He said, “If you let the blood sugar
stay high for a long time, then what you’ll have there
are three blind mice!” Doctor Leibel asked the kids, would they consider participating
in experimental treatment trials. One little girl said, “Not me. I’m perfectly healthy. I’m fine with my insulin. I think those trials
could be pretty risky,” important information
for the scientists to hear, but one little boy said, quietly,
“I’ll do it. Diabetes hurts.” That was it for me. It took all my self-control
not to say, “OK, tour over. We have children worried
about going blind. We have children who are suffering.
Go back to work.” We also give tours to grown-ups,
including recently the artist John Currin and Rachel Feinstein,
whose child was diagnosed recently with type 1 diabetes. They were shocked to find
the labs were a mess and reminded them of their studios. Artists come to basic science
laboratories and see art. This observation is extremely comforting to many of my patients who come on the lab tour
and wonder out loud, can’t I make the scientists
stop goofing around? Can’t I force them
to be more narrowly focused? Pointing out that science is often messy, that the results come
from unexpected directions, go in unexpected places, you can’t see it until you see it. That’s where the discoveries are made. I have already seen examples
of this in my career. When preliminary experiments
were proposed to me in a new field, stem cell research, a few years ago, my response was, “That’s insane.
That’s never going to work.” I was wrong. We can now take skin biopsies
in my patients, turn the cells into stem cells,
and turn them into any cell in the body. When the scientists make heart cells,
they beat in the dish. It’s unbelievable. When we make pancreatic cells,
the cells secrete insulin. In the future, we’ll be able, I think, to have the time when trials are done of transplantation of pancreatic cells that were generated
from my patients skin cells. Another advance
that I would have said was impossible comes from the laboratory
of Doctor Domenico Accili at Columbia. I’ve taught the Columbian
medical students for decades, that only the pancreas can make insulin. Also, incorrect. Doctor Accili has shown
that the intestine can be induced to make insulin. in the future, instead of insulin shots,
my patients might take a pill that causes their gut to make insulin. A cure for diabetes might arise from this very basic research. I tell my patients diagnosed today that I take care of people
who were perfectly healthy; they’ve had diabetes 40, 50 years
and not only that, there is no way that my patients today
will have it this long because the science is moving fast. Meryl was diagnosed
before her second birthday and she’s now 12. She’s had diabetes a decade. Enough. My patients and I are ready for Cubism to emerge
in the science of diabetes. Meryl drew this picture
when she was really little, and when a cure is discovered
for my patients with diabetes it will be a really great day, and we will turn our diabetes center
into a bowling alley. Thank you. (Applause)


62 thoughts on “Type 1 Diabetes: from Cubism to a cure | Robin Goland | TEDxMet”

  • Everyone always misses out on the emotions of diabetes (type 1 and 2) so I wrote a book about it and you can get it for free on Kindle today, if you like that kind of thing!

    UK: http://www.amazon.co.uk/dp/B00CH41L8W/
    US: http://www.amazon.com/o/ASIN/B00CH41L8W/
    CA: http://www.amazon.ca/gp/product/B00CH41L8W
    AU: http://www.amazon.com.au/gp/product/B00CH41L8W/

  • TheClassicGamer - says:

    I have type 1 diabetes and it's the most devastating disease , it's crushed my dreams. My doctors tell me they are extremely close to curing it from stem cell research

  • ruchira prabhath says:

    hi everyone ,if anyone else wants to uncover how can i prevent diabetes try Panlarko Amazing Diabetes Planner (Have a quick look on google cant remember the place now ) ? Ive heard some pretty good things about it and my buddy got great success with it.

  • Itech Prodaja says:

    its not many times im surprized but this video certainly would make anyone think but did you realise there is recent discovery

    students around the world are getting results I learned about this from reading site check it out search google for Diabetes Crusher Tactic


  • Doc informed me I had to cope with type 2 diabetes my whole life. Notwithstanding, I did totally get rid of type 2 diabetes within a few weeks utilizing 100 % natural treatment solution.

  • I don't really care that much about the diesese but the worst part for me is that I can't fullfill my long life dream, joining the military.

  • Justin Jensen says:

    I believe there is a cure for type 1 diabetes, because I have seen some small miracles, I took some supplement polysaccharide peptide rice used in the University of Cebu Philippines and in the temperatures of Philippines detoxed and went from 52 units insulin to 12 with in six weeks, with no change to my diet, people tell me I should have taken it two more months, to reverse completely I have no been able to get the same results here in the US. I seen girls on dialysis that had little chance for a healthy life completely cured, and off dialysis with it so I know it can be very affective. There were Nobel Prices given for the research of Gluco-nutrients & Polysaccharide Peptides so why are we not hearing more about them ?
    I am 38 years type 1 diabetic and heard that turmeric cumin, could help Type 1 Diabetes so I made tea of it and took it three times a day, morning, noon & night. in six months my blood tests showed pro-insulin, my body was making insulin again, but I could not figure how to divide the the pro-insulin into mature insulin & C-peptide as Banting & Best did in their research. I wish I could talk to some open minded people with insight into the surprises I have experienced.

  • Its funny.  I have this weird thing called "a memory"  In around 1997 The New England Journal of Medicine released an article early.  It was "The Cure For Diabetes"  The Managing Editor said he was so excited about this discovery that he had to release it early.  He did.  It said that they took Islet cells from cadavers and injected them into the pancreas and it "CURED" Diabetes.  What ever happened to that cure? Its 20 years later and nothing.

  • People have some love I have diabetes and it's so annoying but I have to keep up with it so be nice it's not like you have it I have 10. Shots a day so be nice ❤️

  • سفيان الثقفي says:

    Insulin would never ever consider as " The treatment of type 1 diabetes" or " The cure of type 1 diabetes" that is false!! Insulin is a temporary solution for diabetics until finding the
    cure that Insulin's companies fight so they don't lose money after diabetes cure found. Since the 1920 until 2017 no cure for the tiny beta cells !! Insulin companies responsible for the late cure of diabetes. And they pay some major doctors to discredit
    any diabetes cure and to promote the Insulin as the only way of diabetics.

  • Unfortunately, doctor's have been telling us that they think they'll be a cure "in the next 10 years", since my FATHER was diagnosed in the 1940's. In all that time, from the point of view of the diabetic, treatment has not changed noticeably. 🙁
    Nor have the complications. My father died of Kidney disease, I have Retinopathy and will be blind, eventually.
    Diabetes DOES HURT. And we PAY FOR THE PRIVILEGE of that hurt. I am forced to pay for a Doctor's appointment, or they refuse to give me prescriptions, that I've been taking for 30 years… That now cost 10 times (or more) than they did OVER THE COUNTER, 10 years ago.
    "In the future" has been spouted to me, and mine, for 30 YEARS! Damn you, and yours, for using hope and the misery of children to profit. Damn. You.

  • Bonnie jw Riley says:

    At the age of 16, my son was suffering from the same respiratory infection I was experiencing at the time. He happened to spend the night at his cousin's house. In the middle of the night he woke with a severe asthmatic reaction and was rushed to the emergency room where steroids were administered to open his airway. I believe his lowered immune and respiratory system reacted to the long haired cats at his cousin's, thus creating the situation. He had never had prior asthma or breathing problems. Within two weeks of this incident and receiving the steroids, he started experiencing symptoms of diabetes. He was diagnosed with type 1 diabetes, though through a research program it was discovered he still has functioning beta cells.There is absolutely NO history of diabetes on my, or his father's, side of the family.
    Unrelated to this incident, but a curiosity to me…A friend had steroid shots in a painful knee. Within a few weeks she started experiencing fatigue and other symptoms. She was diagnosed with an acute leukemia and died a few months later.
    Most doctors have shrugged their shoulders at any possible connection between steroids and these incidents. I believe there is a connection, especially since diabetes is related to an immune disorder.

  • I was diagnosed with type 1 diabetes when I was 21. It's stressful at times but I've adjusted as one does because I have to. My grandfather was also a type 1 diabetic (diagnosed as a child) and his mother initially treated it by basically starving him because there was no alternative. He started taking insulin as a teenager, but the only way to get any sense of one's blood sugar back then was with ketone tests, which basically tell you too little too late—if ketones are showing in your urine, then you've been too high for too long. He eventually died from ketoacidosis in his fifties because he did not manage himself. It is an admittedly awful disease that demands a lot of the patient all day, everyday, but I'm frankly just glad I was born in an age where I wasn't doomed to a young and painful death.

  • K. Ganesan Ganesan says:

    See my videos K. Ganesan Ganesan in YouTube and come to the conclusion whether or not Type 1 Diabetes is treatable or not.

  • 'A new way looking at diabetes' ? I agree. Prevention is better than cure. According to my research, there's a strong link between teens developing type 1 Diabetes due to an immune reaction when red meat and cows milk is consumed. I was hoping that Robin Goland would talk about the ROOT CAUSE….but i'm really disappointed. Stay away from animal products including meat and dairy. That's the BEST place to start.

  • Does anyone know if there has ever been a cure for a disease before that has previously been treatable only and generated a lot of money in the process (like type 1 diabetes)?
    Because a lot of people argue that the pharma industry will never let a cure happen. So I am wondering if this has actually ever happened in the first place or if it always has been "prevented". Because if it did happen, there's a chance it might happen again.

  • Dear Dr,Robin Goland, I would like to thank you for refreshing my knowledge about the history of Diabetes..I think you are on the right path and I wish you all continuing success in your quest to cure the disease.May God continue to bless you and your team.Never mind some of those negative comments,they need to get educated.

  • hi guys, wants to know more about treating diabetes the best success that i've ever had is called the Diabetes Crusher Tactic (just google it) without a doubt the no.1 course that I've had.

  • Kudos for the Video clip! Sorry for the intrusion, I am interested in your thoughts. Have you heard about – Patlarny Diabetes Ruins Principle (do a google search)? It is an awesome one off guide for destroying diabetes without the hard work. Ive heard some decent things about it and my m8 at last got excellent results with it.

  • It amazes me how many people are in attendance at this talk.  If you see alternative ways of treating these issues there is a far less crowd.  Please people,  look up Robert Morse on YouTube.  He is a speaker for healing and the truth about medications.  They don't work.  They keep people sick and make them more sick.  To me, this woman is promoting drugs and not a cure.  She says they are looking for a cure, but they are not.  I'm surprised this is on here.  I can't believe what she is saying.

  • Oh my god, I can't even watch the rest of it.  Putting the labs next to the offices.  Give me a break!!!  She must be working for the drug companies.  This is not the answer!!!!  OK, I'm done!!!!!!!!!!!!!!!!!!!!!

  • I'll be skeptical til the day I can get cured. I truly do not believe there is a demand to find a cure since our disease is manageable. I'm also curious if the cure this woman is talking about would apply for Type 1 and also Type 2 or if the cure mentioned would only apply to one type?

  • My heart breaks for our tiny heroes who have to go through all the needles, calculations and forced eating. My daughter was diagnosed this March at just under 2 yrs 3months old. I hate this deseas. My heart breaks for the little ones.

  • I'm type 1 for 18years.I didn't smoke,drink, very clean lifestyle,exercise 5 times aweek. At 55 my life is great,praise our Lord Jesus Christ every day

  • "science moving fast." ELEPHANT MANURE!!! It's 4 years later and still nothing!!
    this talk was worthless. Don't bother.
    T1 of 40+ years

  • The brain also makes it. Take a tablespoon of cold pressed non-gmo coconut oil before and after meals and eventually the brain takes over the job of the pancreas.

  • Big Pharma/FDA will always try to slow down the development of any advancement for even diabetic management devices, pumps, CGM, artificial pancreas system, etc A cure? That is because there is no recurring cost in a cure.

  • How will you overcome the immune system attacking beta cells? That is what started the whole process and keeps type 1 going.

  • Hi I'm tayp 1 Diabetes peshent 20 yarsh old I'm Amit davda fom Gujrat Jamnagar nevarmerid Hindu vejiteriyan noshmok no drinks biznesh welshetl dob 1983 kontekno 7777921160 9824256817

  • What is the point of this presentation? For 80 there have been no advances in the science of diabetes, but we recently started working, so don’t worry!! Please don’t give a public speech unless a sound solution has been discovered.

    All the potential solutions showcased near the end of the video are still challenged, so what is actually required to move forward, faster ? Funding ? Human Resources ? Help with regulation ? …. the actual point of this video is just to tell her bravo and thank you for your efforts

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