Gut bacteria and antibiotics: Michael Fischbach looks for answers

I’m Michael Fischbach. I’m in the Department of Bioengineering and Therapeutic Sciences at UCSF, and I’m the PI on a new grant from the Keck Foundation that’s titled Beyond the Human Microbiome Project: The Gut Microbiome as an Antibiotic Discovery Factory. The purpose of this grant is to try to begin figuring out an interesting conundrum that’s only […]

Why Do Bacteria Develop Antibiotic Resistance?

Despite their beauty, roses always seem to cause innocuous little cuts with their sharp thorns. But let’s flashback to the 1930s. If bacteria managed to get into the bloodstream through that cut, it could have been disastrous since antibiotics had yet to become widely available. Fast-forward to today, and we wouldn’t think twice about a small cut thanks […]

David McAdams on a post-antibiotic world

[MUSIC] Let’s look at the first drug used to treat human disease: penicillin. Here we have a sign: “Penicillin cures gonorrhea in four hours.” Okay. That was the 1940s. How could it do that? Because it killed the bacteria that caused gonorrhea. Okay. Bacteria that it kills, we call susceptible. Those are susceptible bacteria. But there were some […]

Fighting Antibiotic Resistance: Fan Liu

In my work, I’m in a constant race against bacteria. Antibiotic resistance has become an increasingly challenging problem in the world. In the United States alone, every year, we have more than 2 million people that become seriously ill because of these infections. Bacteria are fascinating little creatures. They grow really really fast, and they are developing resistance […]

Antibiotics Unearthed

Antibiotics Unearthed is a project that we’re running with the Microbiology Society. It’s a citizen science project where we’re getting members of the public to go out and gather soil, and we’re looking at that soil to see if there are bacteria in it that might be producing new antibiotics. We need to look for new antibiotics because […]

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